OncoTargets and Therapy (Sep 2022)

Case Report and Review of Literature: Camrelizumab Combined with Fuzuloparib and Apatinib for Platinum-Resistant Recurrent Ovarian Cancer

  • Wu Y,
  • Zhang X,
  • Li L,
  • Yang W,
  • Yan Z,
  • Gu C,
  • Zhang Z,
  • Zhou J,
  • Liu L,
  • Ye M,
  • Meng Y

Journal volume & issue
Vol. Volume 15
pp. 973 – 979

Abstract

Read online

Yawen Wu,1,2 Xiaoyan Zhang,1,2 Lian Li,2 Wen Yang,2 Zhifeng Yan,2 Chenglei Gu,2 Zhe Zhang,2 Jiahuan Zhou,3 Lulu Liu,3 Mingxia Ye,2 Yuanguang Meng2 1School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Department of Gynecology and Obstetrics, The First Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 3Department of Clinical Research & Development, Jiangsu Hengrui Pharmaceuticals Co., Ltd, Shanghai, People’s Republic of ChinaCorrespondence: Mingxia Ye; Yuanguang Meng, Email [email protected]; [email protected]: The mortality rate of ovarian cancer (OC) ranks first among female genital tract malignant tumors, which seriously threatens women’s life and health. Because of its insidious onset and poor prognosis, it has become a thorny problem in the clinic, especially for patients with platinum-resistant recurrent ovarian cancer (PROC). In recent years, the medical treatment of OC has made gratifying results, bringing hope to the patients.Case Description: A 54-year-old OC patient who has failed previous neoadjuvant chemotherapy, cytoreductive surgery, and postoperative chemotherapy was diagnosed with PROC. Then she received combination treatment of fuzuloparib (100mg PO BID), apatinib (250mg PO QD), and camrelizumab (200mg IV Q3W) for every 3-week cycle in a Phase II study for PROC patients. In the phase II study, her condition stabilized, responded well to treatment with a sharp decrease by 91.14% of target lesions and disappearances of non-target lesions, and continued to receive regular treatment with progression-free survival exceeding 15 months and no serious adverse events.Conclusion: The present case proves PROC patients might have a sustained response to triplet combination with camrelizumab, combined with fuzuloparib and apatinib.Keywords: recurrent ovarian cancer, platinum resistance, PARP inhibitors, immunotherapy, antiangiogenic agents

Keywords