Breast Cancer: Targets and Therapy (Jan 2022)

Treatment Strategies Against Triple-Negative Breast Cancer: An Updated Review

  • Maqbool M,
  • Bekele F,
  • Fekadu G

Journal volume & issue
Vol. Volume 14
pp. 15 – 24

Abstract

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Mudasir Maqbool,1 Firomsa Bekele,2 Ginenus Fekadu3,4 1Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India; 2Department of Pharmacy, College of Health Sciences, Mettu University, Mettu, Ethiopia; 3School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; 4Department of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, EthiopiaCorrespondence: Firomsa BekeleDepartment of Pharmacy, College of Health Science, Mettu University, Mettu, EthiopiaEmail [email protected]: Triple-negative breast cancer (TNBC) is associated with an increased risk of early recurrence and distant metastasis, as well as the development of therapeutic resistance and poor prognosis. TNBC is characterized by a wide range of genetic, immunophenotypic, morphological, and clinical features. TNBC is coined to describe cancers that lack estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). As a result, hormonal or trastuzumab-based treatments are ineffective in TNBC patients. TNBCs are biologically aggressive, and despite some evidence that they respond to treatment better than other forms of breast cancer, the prognosis remains poor. This is attributed to a shorter disease-free interval in adjuvant and neoadjuvant settings, as well as a more aggressive metastatic course. TNBC has a lot of clinical ramifications. In terms of new treatment methods, TNBC has lagged behind other types of breast cancer. There are not many options for treating this form of breast cancer because it is progressive. Many effective treatments for most breast cancers block the growth-stimulating effects of ER, PR, and/or HER2, leaving TNBC with few choices. Finding new and effective treatment options for TNBC remains a critical clinical need. To develop more effective drugs, new experimental approaches must be tested in patients with TNBC.Keywords: breast cancer, progesterone receptor, genetic, human epidermal growth factor receptor 2

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