FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

Dailu Chen; Sofia Bali; Ruhar Singh; Aleksandra Wosztyl; Vishruth Mullapudi; Jaime Vaquer-Alicea; Parvathy Jayan; Shamiram Melhem; Harro Seelaar; John C. van Swieten; Marc I. Diamond; Lukasz A. Joachimiak

doi:10.1038/s41467-023-37274-6

Nature Communications (Mar 2023)

FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

Dailu Chen,
Sofia Bali,
Ruhar Singh,
Aleksandra Wosztyl,
Vishruth Mullapudi,
Jaime Vaquer-Alicea,
Parvathy Jayan,
Shamiram Melhem,
Harro Seelaar,
John C. van Swieten,
Marc I. Diamond,
Lukasz A. Joachimiak

Affiliations

Dailu Chen: Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center
Sofia Bali: Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center
Ruhar Singh: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Aleksandra Wosztyl: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Vishruth Mullapudi: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Jaime Vaquer-Alicea: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Parvathy Jayan: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Shamiram Melhem: Department of Neurology & Alzheimer Center, Erasmus Medical Center
Harro Seelaar: Department of Neurology & Alzheimer Center, Erasmus Medical Center
John C. van Swieten: Department of Neurology & Alzheimer Center, Erasmus Medical Center
Marc I. Diamond: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Lukasz A. Joachimiak: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-023-37274-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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The authors used multi-disciplinary approaches to understand the structural mechanism underlying spontaneous aggregation of tau encoding an S320F FTD-tau mutant. Understanding the mechanisms of tau aggregation will help identify novel methods to regulate its misfolding.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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