Current therapeutic strategies for respiratory diseases using mesenchymal stem cells
Ming‐yao Wang,
Ting‐yue Zhou,
Zhi‐dong Zhang,
Hao‐yang Liu,
Zhi‐yao Zheng,
Hui‐qi Xie
Affiliations
Ming‐yao Wang
Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute Med‐X Center for Materials State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China
Ting‐yue Zhou
Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute Med‐X Center for Materials State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China
Zhi‐dong Zhang
Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute Med‐X Center for Materials State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China
Hao‐yang Liu
Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute Med‐X Center for Materials State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China
Zhi‐yao Zheng
Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute Med‐X Center for Materials State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China
Hui‐qi Xie
Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute Med‐X Center for Materials State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China
Abstract Mesenchymal stromal/stem cells (MSCs) have a great potential to proliferate, undergo multi‐directional differentiation, and exert immunoregulatory effects. There is already much enthusiasm for their therapeutic potentials for respiratory inflammatory diseases. Although the mechanism of MSCs‐based therapy has been well explored, only a few articles have summarized the key advances in this field. We hereby provide a review over the latest progresses made on the MSCs‐based therapies for four types of inflammatory respiratory diseases, including idiopathic pulmonary fibrosis, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and asthma, and the uncovery of their underlying mechanisms from the perspective of biological characteristics and functions. Furthermore, we have also discussed the advantages and disadvantages of the MSCs‐based therapies and prospects for their optimization.
