Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

Terkild Brink Buus; Niels Ødum; Carsten Geisler; Jens Peter Holst Lauritsen

doi:10.1038/s41467-017-01963-w

Nature Communications (Dec 2017)

Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

Terkild Brink Buus,
Niels Ødum,
Carsten Geisler,
Jens Peter Holst Lauritsen

Affiliations

Terkild Brink Buus: Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
Niels Ødum: Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
Carsten Geisler: Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
Jens Peter Holst Lauritsen: Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-017-01963-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Mouse γδ T cells have diverse functional subsets, but how these subsets are programmed during their development is still unclear. Here the authors show that three surface markers, CD117, CD200 and CD371, refine the development of γδ T cells in the thymus into three pathways programming distinct γδ T cell subsets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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