Nature Communications (Jul 2020)

Targeting QKI-7 in vivo restores endothelial cell function in diabetes

  • Chunbo Yang,
  • Magdalini Eleftheriadou,
  • Sophia Kelaini,
  • Thomas Morrison,
  • Marta Vilà González,
  • Rachel Caines,
  • Nicola Edwards,
  • Andrew Yacoub,
  • Kevin Edgar,
  • Arya Moez,
  • Aleksandar Ivetic,
  • Anna Zampetaki,
  • Lingfang Zeng,
  • Fiona L. Wilkinson,
  • Noemi Lois,
  • Alan W. Stitt,
  • David J. Grieve,
  • Andriana Margariti

DOI
https://doi.org/10.1038/s41467-020-17468-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction, and that in vivo QKI-7 silencing improves blood flow recovery in diabetic mice with limb ischemia.