Clinical implication of endothelial dysfunction in patients with essential arterial hypertension and urate dysbolism with renal damage

Abstract

Aim. To study correlations between severity of hyperuricemia, endothelial dysfunction (ED) and arterial atherosclerosis (AS). Material and methods. A total of 50 patients with essential hypertension of degree I-II free of associated clinical conditions entered the trial. The study group consisted of 40 patients with hyperuricemia, the control group - of 10 patients with normal blood serum levels of uric acid. Results. The study group patients versus controls had significantly higher albuminuria (93.5±1.7 and 60.7±2.2 mg/l; p < 0.001), plasmic concentration of endotheline-1 (6.8±0.3 and 4.9±0.2 pg/ml; p < 0.001)and thickness of the intima-media complex of the common carotid artery (1.36±0.02 and 1.1±0.04; p < 0.001). All the indices correlated directly and significantly. Conclusion. Patients with arterial hypertension of the first-second degree with persistent elevated levels of uric acid in blood serum had significantly higher levels of ED markers: albuminuria, plasmic endothelin concentration. Hyperuricemia and ED in such patients lead to more active progression of atherosclerotic vascular lesion.

Keywords

• albuminuria
• arterial hypertension
• atherosclerotic lesion of the vessels
• hyperuricemia
• uric acid
• intima-media thickness
• endothelial dysfunction
• endothelin-1