Frontiers in Neuroscience (Dec 2023)
Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations
- Heta Helakari,
- Heta Helakari,
- Matti Järvelä,
- Matti Järvelä,
- Tommi Väyrynen,
- Tommi Väyrynen,
- Johanna Tuunanen,
- Johanna Tuunanen,
- Johanna Piispala,
- Mika Kallio,
- Seyed Mohsen Ebrahimi,
- Seyed Mohsen Ebrahimi,
- Valter Poltojainen,
- Valter Poltojainen,
- Janne Kananen,
- Janne Kananen,
- Janne Kananen,
- Ahmed Elabasy,
- Ahmed Elabasy,
- Niko Huotari,
- Niko Huotari,
- Lauri Raitamaa,
- Lauri Raitamaa,
- Timo Tuovinen,
- Timo Tuovinen,
- Vesa Korhonen,
- Vesa Korhonen,
- Maiken Nedergaard,
- Maiken Nedergaard,
- Vesa Kiviniemi,
- Vesa Kiviniemi
Affiliations
- Heta Helakari
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Heta Helakari
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Matti Järvelä
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Matti Järvelä
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Tommi Väyrynen
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Tommi Väyrynen
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Johanna Tuunanen
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Johanna Tuunanen
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Johanna Piispala
- Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland
- Mika Kallio
- Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland
- Seyed Mohsen Ebrahimi
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Seyed Mohsen Ebrahimi
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Valter Poltojainen
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Valter Poltojainen
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Janne Kananen
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Janne Kananen
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Janne Kananen
- Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland
- Ahmed Elabasy
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Ahmed Elabasy
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Niko Huotari
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Niko Huotari
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Lauri Raitamaa
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Lauri Raitamaa
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Timo Tuovinen
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Timo Tuovinen
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Vesa Korhonen
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Vesa Korhonen
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- Maiken Nedergaard
- Center of Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark
- Maiken Nedergaard
- Center of Translational Neuromedicine, University of Rochester, Rochester, NY, United States
- Vesa Kiviniemi
- Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
- Vesa Kiviniemi
- Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
- DOI
- https://doi.org/10.3389/fnins.2023.1275184
- Journal volume & issue
-
Vol. 17
Abstract
IntroductionSleep increases brain fluid transport and the power of pulsations driving the fluids. We investigated how sleep deprivation or electrophysiologically different stages of non-rapid-eye-movement (NREM) sleep affect the human brain pulsations.MethodsFast functional magnetic resonance imaging (fMRI) was performed in healthy subjects (n = 23) with synchronous electroencephalography (EEG), that was used to verify arousal states (awake, N1 and N2 sleep). Cardiorespiratory rates were verified with physiological monitoring. Spectral power analysis assessed the strength, and spectral entropy assessed the stability of the pulsations.ResultsIn N1 sleep, the power of vasomotor (VLF < 0.1 Hz), but not cardiorespiratory pulsations, intensified after sleep deprived vs. non-sleep deprived subjects. The power of all three pulsations increased as a function of arousal state (N2 > N1 > awake) encompassing brain tissue in both sleep stages, but extra-axial CSF spaces only in N2 sleep. Spectral entropy of full band and respiratory pulsations decreased most in N2 sleep stage, while cardiac spectral entropy increased in ventricles.DiscussionIn summary, the sleep deprivation and sleep depth, both increase the power and harmonize the spectral content of human brain pulsations.
Keywords
