Nature Communications (Jun 2020)
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
- Hye Yeon Choi,
- Hifzur R. Siddique,
- Mengmei Zheng,
- Yi Kou,
- Da-Wei Yeh,
- Tatsuya Machida,
- Chia-Lin Chen,
- Dinesh Babu Uthaya Kumar,
- Vasu Punj,
- Peleg Winer,
- Alejandro Pita,
- Linda Sher,
- Stanley M. Tahara,
- Ratna B. Ray,
- Chengyu Liang,
- Lin Chen,
- Hidekazu Tsukamoto,
- Keigo Machida
Affiliations
- Hye Yeon Choi
- Department of Molecular Microbiology and Immunology, University of Southern California
- Hifzur R. Siddique
- Department of Molecular Microbiology and Immunology, University of Southern California
- Mengmei Zheng
- Department of Molecular Microbiology and Immunology, University of Southern California
- Yi Kou
- Department of Chemistry and Biological Sciences, University of Southern California
- Da-Wei Yeh
- Department of Molecular Microbiology and Immunology, University of Southern California
- Tatsuya Machida
- Department of Molecular Microbiology and Immunology, University of Southern California
- Chia-Lin Chen
- Department of Molecular Microbiology and Immunology, University of Southern California
- Dinesh Babu Uthaya Kumar
- Department of Molecular Microbiology and Immunology, University of Southern California
- Vasu Punj
- Department of Medicine, University of Southern California
- Peleg Winer
- Department of Molecular Microbiology and Immunology, University of Southern California
- Alejandro Pita
- Department of Surgery, University of Southern California
- Linda Sher
- Department of Surgery, University of Southern California
- Stanley M. Tahara
- Department of Molecular Microbiology and Immunology, University of Southern California
- Ratna B. Ray
- Saint Louis University
- Chengyu Liang
- Department of Molecular Microbiology and Immunology, University of Southern California
- Lin Chen
- Department of Chemistry and Biological Sciences, University of Southern California
- Hidekazu Tsukamoto
- Department of Pathology, Keck School of Medicine, University of Southern California
- Keigo Machida
- Department of Molecular Microbiology and Immunology, University of Southern California
- DOI
- https://doi.org/10.1038/s41467-020-16616-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tumorigenesis.
