Nature Communications (Sep 2019)
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma
- Zhaoming Li,
- Xudong Zhang,
- Weili Xue,
- Yanjie Zhang,
- Chaoping Li,
- Yue Song,
- Mei Mei,
- Lisha Lu,
- Yingjun Wang,
- Zhiyuan Zhou,
- Mengyuan Jin,
- Yangyang Bian,
- Lei Zhang,
- Xinhua Wang,
- Ling Li,
- Xin Li,
- Xiaorui Fu,
- Zhenchang Sun,
- Jingjing Wu,
- Feifei Nan,
- Yu Chang,
- Jiaqin Yan,
- Hui Yu,
- Xiaoyan Feng,
- Guannan Wang,
- Dandan Zhang,
- Xuefei Fu,
- Yuan Zhang,
- Ken H. Young,
- Wencai Li,
- Mingzhi Zhang
Affiliations
- Zhaoming Li
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Xudong Zhang
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Weili Xue
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Yanjie Zhang
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Chaoping Li
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Yue Song
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Mei Mei
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Lisha Lu
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Yingjun Wang
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Zhiyuan Zhou
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Mengyuan Jin
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Yangyang Bian
- Medical Research Centre, The First Affiliated Hospital of Zhengzhou University
- Lei Zhang
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Xinhua Wang
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Ling Li
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Xin Li
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Xiaorui Fu
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Zhenchang Sun
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Jingjing Wu
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Feifei Nan
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Yu Chang
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Jiaqin Yan
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Hui Yu
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Xiaoyan Feng
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- Guannan Wang
- Department of Pathology, The First Affiliated Hospital of Zhengzhou University
- Dandan Zhang
- Department of Pathology, The First Affiliated Hospital of Zhengzhou University
- Xuefei Fu
- Novogene Bioinformatics Technology Co, Ltd
- Yuan Zhang
- The Academy of Medical Science of Zhengzhou University
- Ken H. Young
- Department of Hematopathology, The University of Texas MD Anderson Cancer Center
- Wencai Li
- Department of Pathology, The First Affiliated Hospital of Zhengzhou University
- Mingzhi Zhang
- Department of Oncology, The First Affiliated Hospital of Zhengzhou University
- DOI
- https://doi.org/10.1038/s41467-019-12032-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive disease. Here, the authors identify recurrent somatic mutations of GNAQ in NKTCL, and model how this mutation contributes to NKTCL pathogenesis.
