Nature Communications (Dec 2016)

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

  • Emeline Bon,
  • Virginie Driffort,
  • Frédéric Gradek,
  • Carlos Martinez-Caceres,
  • Monique Anchelin,
  • Pablo Pelegrin,
  • Maria-Luisa Cayuela,
  • Séverine Marionneau-Lambot,
  • Thibauld Oullier,
  • Roseline Guibon,
  • Gaëlle Fromont,
  • Jorge L. Gutierrez-Pajares,
  • Isabelle Domingo,
  • Eric Piver,
  • Alain Moreau,
  • Julien Burlaud-Gaillard,
  • Philippe G. Frank,
  • Stéphan Chevalier,
  • Pierre Besson,
  • Sébastien Roger

DOI
https://doi.org/10.1038/ncomms13648
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 18

Abstract

Read online

The capacity of cancer cells to migrate is intimately linked to their ability to induce metastasis. Here the authors show that the sodium channel β4 subunit regulates breast cancer cell migration via inhibition of RhoA activation, independently from its function as an auxiliary protein of the sodium channel.