Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

Wenting Liu; Yi-Fang Zhong; Liu-Yi Liu; Chu-Tong Shen; Wenjuan Zeng; Fuyi Wang; Danzhou Yang; Zong-Wan Mao

doi:10.1038/s41467-018-05810-4

Nature Communications (Aug 2018)

Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

Wenting Liu,
Yi-Fang Zhong,
Liu-Yi Liu,
Chu-Tong Shen,
Wenjuan Zeng,
Fuyi Wang,
Danzhou Yang,
Zong-Wan Mao

Affiliations

Wenting Liu: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Yi-Fang Zhong: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Liu-Yi Liu: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Chu-Tong Shen: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Wenjuan Zeng: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences
Fuyi Wang: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences
Danzhou Yang: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University Center for Cancer Research, Purdue Institute for Drug Discovery, Purdue University
Zong-Wan Mao: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University

DOI: https://doi.org/10.1038/s41467-018-05810-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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DNA G-quadruplexes occur in oncologically relevant regions, thus are interesting targets for cancer research and treatment. Here, the authors solved the 1:1 and 4:2 (ligand/DNA) NMR structures of human telomeric DNA in complex with platinum(II)-tripod ligand and show that the binding is dynamic.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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