Nature Communications (Oct 2020)

Selective inhibition of human translation termination by a drug-like compound

  • Wenfei Li,
  • Stacey Tsai-Lan Chang,
  • Fred. R. Ward,
  • Jamie H. D. Cate

DOI
https://doi.org/10.1038/s41467-020-18765-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1).