Neutrophil-to-lymphocyte ratio and chemotherapy response score as prognostic markers in ovarian cancer patients treated with neoadjuvant chemotherapy

M. Liontos; A. Andrikopoulou; K. Koutsoukos; C. Markellos; E. Skafida; O. Fiste; M. Kaparelou; N. Thomakos; D. Haidopoulos; A. Rodolakis; M. A. Dimopoulos; F. Zagouri

doi:10.1186/s13048-021-00902-0

Journal of Ovarian Research (Nov 2021)

Neutrophil-to-lymphocyte ratio and chemotherapy response score as prognostic markers in ovarian cancer patients treated with neoadjuvant chemotherapy

M. Liontos,
A. Andrikopoulou,
K. Koutsoukos,
C. Markellos,
E. Skafida,
O. Fiste,
M. Kaparelou,
N. Thomakos,
D. Haidopoulos,
A. Rodolakis,
M. A. Dimopoulos,
F. Zagouri

Affiliations

M. Liontos: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
A. Andrikopoulou: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
K. Koutsoukos: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
C. Markellos: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
E. Skafida: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
O. Fiste: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
M. Kaparelou: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
N. Thomakos: Department of Obstetrics and Gynecology, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
D. Haidopoulos: Department of Obstetrics and Gynecology, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
A. Rodolakis: Department of Obstetrics and Gynecology, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
M. A. Dimopoulos: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens
F. Zagouri: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens

DOI: https://doi.org/10.1186/s13048-021-00902-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 10

Abstract

Read online

Research highlights Biomarkers that would predict response to neoadjuvant chemotherapy in advanced ovarian cancer patients are eagerly needed: • Neutrophil to Lymphocyte Ratio (NLR) is an indicator of systemic inflammatory response to the malignancy. • NLR was evaluated in 132 patients undergoing Neoadjuvant Chemotherapy for advanced ovarian cancer. • Elevated NLR was associated with worse prognosis. • No association between NLR and response to chemotherapy was noted.

Published in Journal of Ovarian Research

ISSN: 1757-2215 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://ovarianresearch.biomedcentral.com/

About the journal