Nature Communications (Sep 2021)

Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

  • David M. Zhang,
  • Rachita Navara,
  • Tiankai Yin,
  • Jeffrey Szymanski,
  • Uri Goldsztejn,
  • Camryn Kenkel,
  • Adam Lang,
  • Cedric Mpoy,
  • Catherine E. Lipovsky,
  • Yun Qiao,
  • Stephanie Hicks,
  • Gang Li,
  • Kaitlin M. S. Moore,
  • Carmen Bergom,
  • Buck E. Rogers,
  • Clifford G. Robinson,
  • Phillip S. Cuculich,
  • Julie K. Schwarz,
  • Stacey L. Rentschler

DOI
https://doi.org/10.1038/s41467-021-25730-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.