Nature Communications (Jan 2020)

The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus

  • Kathleen E. Orrell,
  • Michael J. Mansfield,
  • Andrew C. Doxey,
  • Roman A. Melnyk

DOI
https://doi.org/10.1038/s41467-020-14306-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Large Clostridial toxins infiltrate host cells using a translocation domain (LCT-T). Here, using a genomics-driven approach and functional assays, the authors uncover the presence of distant LCT-T homologs in bacteria outside clostridia and provide evidence for a toxic effector function in the gammaproteobacterium Serratia marcescens.