PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

Giuseppe Ercolano; Alejandra Gomez-Cadena; Nina Dumauthioz; Giulia Vanoni; Mario Kreutzfeldt; Tania Wyss; Liliane Michalik; Romain Loyon; Angela Ianaro; Ping-Chih Ho; Christophe Borg; Manfred Kopf; Doron Merkler; Philippe Krebs; Pedro Romero; Sara Trabanelli; Camilla Jandus

doi:10.1038/s41467-021-22764-2

Nature Communications (May 2021)

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

Giuseppe Ercolano,
Alejandra Gomez-Cadena,
Nina Dumauthioz,
Giulia Vanoni,
Mario Kreutzfeldt,
Tania Wyss,
Liliane Michalik,
Romain Loyon,
Angela Ianaro,
Ping-Chih Ho,
Christophe Borg,
Manfred Kopf,
Doron Merkler,
Philippe Krebs,
Pedro Romero,
Sara Trabanelli,
Camilla Jandus

Affiliations

Giuseppe Ercolano: Department of Pathology and Immunology, University of Geneva
Alejandra Gomez-Cadena: Department of Pathology and Immunology, University of Geneva
Nina Dumauthioz: Department of Oncology UNIL CHUV, University of Lausanne
Giulia Vanoni: Department of Oncology UNIL CHUV, University of Lausanne
Mario Kreutzfeldt: Department of Pathology and Immunology, Division of Clinical Pathology, University and University Hospitals of Geneva
Tania Wyss: Department of Oncology UNIL CHUV, University of Lausanne
Liliane Michalik: Center for Integrative Genomics, University of Lausanne
Romain Loyon: Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique
Angela Ianaro: Department of Pharmacy, University of Naples Federico II
Ping-Chih Ho: Department of Oncology UNIL CHUV, University of Lausanne
Christophe Borg: Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique
Manfred Kopf: Institute of Molecular Health Sciences, ETH Zürich
Doron Merkler: Department of Pathology and Immunology, Division of Clinical Pathology, University and University Hospitals of Geneva
Philippe Krebs: Institute of Pathology, University of Bern
Pedro Romero: Department of Oncology UNIL CHUV, University of Lausanne
Sara Trabanelli: Department of Pathology and Immunology, University of Geneva
Camilla Jandus: Department of Pathology and Immunology, University of Geneva

DOI: https://doi.org/10.1038/s41467-021-22764-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Group 2 innate lymphoid cells (ILC2s) are a component of type 2 immune response recently described to be involved in the regulation of anti-tumor immune responses. Here, the authors show that the expression of the peroxisome proliferator-activated receptor γ (PPAPγ) in human and mouse ILC2 sustains type-2 cytokines secretion and support their pro-tumorigenic role in preclinical cancer models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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