Disrupted relationship between intrinsic neural timescales and alpha peak frequency during unconscious states – A high-density EEG study
Andrea Buccellato,
Di Zang,
Federico Zilio,
Javier Gomez-Pilar,
Zhe Wang,
Zengxin Qi,
Ruizhe Zheng,
Zeyu Xu,
Xuehai Wu,
Patrizia Bisiacchi,
Alessandra Del Felice,
Ying Mao,
Georg Northoff
Affiliations
Andrea Buccellato
Padova Neuroscience Center, University of Padova, Padova, Italy; Department of General Psychology, University of Padova, Padova, Italy; Corresponding authors.
Di Zang
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University,Shanghai, 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200040, China; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, 200032, China; National Center for Neurological Disorders, Shanghai, 200040, China; Neurosurgical Institute of Fudan University, Shanghai, 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China
Federico Zilio
Department of Philosophy, Sociology, Education and Applied Psychology, University of Padova, Padua, Italy
Javier Gomez-Pilar
Biomedical Engineering Group, University of Valladolid, Paseo de Belén, 15, Valladolid 47011, Spain; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, (CIBER-BBN), Valladolid, Spain
Zhe Wang
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University,Shanghai, 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200040, China; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, 200032, China; National Center for Neurological Disorders, Shanghai, 200040, China; Neurosurgical Institute of Fudan University, Shanghai, 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China
Zengxin Qi
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University,Shanghai, 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200040, China; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, 200032, China; National Center for Neurological Disorders, Shanghai, 200040, China; Neurosurgical Institute of Fudan University, Shanghai, 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China
Ruizhe Zheng
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University,Shanghai, 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200040, China; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, 200032, China; National Center for Neurological Disorders, Shanghai, 200040, China; Neurosurgical Institute of Fudan University, Shanghai, 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China
Zeyu Xu
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University,Shanghai, 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200040, China; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, 200032, China; National Center for Neurological Disorders, Shanghai, 200040, China; Neurosurgical Institute of Fudan University, Shanghai, 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China
Xuehai Wu
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University,Shanghai, 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200040, China; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, 200032, China; National Center for Neurological Disorders, Shanghai, 200040, China; Neurosurgical Institute of Fudan University, Shanghai, 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China
Patrizia Bisiacchi
Padova Neuroscience Center, University of Padova, Padova, Italy; Department of General Psychology, University of Padova, Padova, Italy
Alessandra Del Felice
Padova Neuroscience Center, University of Padova, Padova, Italy; Department of Neuroscience, Section of Rehabilitation, University of Padova, Padova, Italy
Ying Mao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University,Shanghai, 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200040, China; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, 200032, China; National Center for Neurological Disorders, Shanghai, 200040, China; Neurosurgical Institute of Fudan University, Shanghai, 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China; Corresponding authors.
Georg Northoff
Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health, Royal Ottawa Mental Health Centre and University of Ottawa, Ottawa, Ontario K1Z7K4, Canada; Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang Province, China; Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou 310013, Zhejiang Province, China; Corresponding authors.
Our brain processes the different timescales of our environment's temporal input stochastics. Is such a temporal input processing mechanism key for consciousness? To address this research question, we calculated measures of input processing on shorter (alpha peak frequency, APF) and longer (autocorrelation window, ACW) timescales on resting-state high-density EEG (256 channels) recordings and compared them across different consciousness levels (awake/conscious, ketamine and sevoflurane anaesthesia, unresponsive wakefulness, minimally conscious state). We replicate and extend previous findings of: (i) significantly longer ACW values, consistently over all states of unconsciousness, as measured with ACW-0 (an unprecedented longer version of the well-know ACW-50); (ii) significantly slower APF values, as measured with frequency sliding, in all four unconscious states. Most importantly, we report a highly significant correlation of ACW-0 and APF in the conscious state, while their relationship is disrupted in the unconscious states. In sum, we demonstrate the relevance of the brain's capacity for input processing on shorter (APF) and longer (ACW) timescales - including their relationship - for consciousness. Albeit indirectly, e.g., through the analysis of electrophysiological activity at rest, this supports the mechanism of temporo-spatial alignment to the environment's temporal input stochastics, through relating different neural timescales, as one key predisposing factor of consciousness.
