Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model

Laura Tomas-Roca; Zhen Qiu; Erik Fransén; Ragini Gokhale; Edita Bulovaite; David J. Price; Noboru H. Komiyama; Seth G. N. Grant

doi:10.1038/s41467-022-34131-w

Nature Communications (Nov 2022)

Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model

Laura Tomas-Roca,
Zhen Qiu,
Erik Fransén,
Ragini Gokhale,
Edita Bulovaite,
David J. Price,
Noboru H. Komiyama,
Seth G. N. Grant

Affiliations

Laura Tomas-Roca: Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh
Zhen Qiu: Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh
Erik Fransén: Science for Life Laboratory, KTH Royal Institute of Technology
Ragini Gokhale: Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh
Edita Bulovaite: Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh
David J. Price: Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh
Noboru H. Komiyama: Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh
Seth G. N. Grant: Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh

DOI: https://doi.org/10.1038/s41467-022-34131-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Brain-wide mapping of synapse molecular composition in Pax6 mutant mice shows remodelling and restoration of synaptome architecture during development, a possible means of conferring resilience to genetic disorders.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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