Pediatric Reports (Jun 2011)

Pathobiology of ALK-negative anaplastic large cell lymphoma

  • Stefano A. Pileri,
  • Claudio Agostinelli,
  • Francesco Bacci,
  • Elena Sabattini,
  • Carlo Sagramoso,
  • Brunangelo Falini,
  • Pier Paolo Piccaluga

DOI
https://doi.org/10.4081/pr.2011.s2.e5

Abstract

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The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented.