Nature Communications (Nov 2016)

In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

  • Maria Cristina Lo Giudice,
  • Luciana M. Herda,
  • Ester Polo,
  • Kenneth A. Dawson

DOI
https://doi.org/10.1038/ncomms13475
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

The protein corona on nanoparticle surfaces leads to presentation of receptor-binding motifs and defines the cellular interactions. Here, the authors use antibody mapping fluorescent quantum dot reporters, and flow cytometry to measure the availability of these recognition motifs in biological media.