The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

• Obul R. Bandapalli,
• Stephanie Schuessele,
• Joachim B. Kunz,
• Tobias Rausch,
• Adrian M. Stütz,
• Noa Tal,
• Ifat Geron,
• Nava Gershman,
• Shai Izraeli,
• Juliane Eilers,
• Nina Vaezipour,
• Renate Kirschner-Schwabe,
• Jana Hof,
• Arend von Stackelberg,
• Martin Schrappe,
• Martin Stanulla,
• Martin Zimmermann,
• Rolf Koehler,
• Smadar Avigad,
• Rupert Handgretinger,
• Viktoras Frismantas,
• Jean Pierre Bourquin,
• Beat Bornhauser,
• Jan O. Korbel,
• Martina U. Muckenthaler,
• Andreas E. Kulozik

Affiliations

Obul R. Bandapalli

Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital, University of Heidelberg, Germany;Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany

Stephanie Schuessele

Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital, University of Heidelberg, Germany;Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany

Joachim B. Kunz

Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital, University of Heidelberg, Germany;Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany

Tobias Rausch

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany

Adrian M. Stütz

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany

Noa Tal

Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel

Ifat Geron

Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel;Division of Biological Sciences and Department of Medicine Stem Cell Program, University of California, San Diego, La Jolla, CA, USA

Nava Gershman

Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel

Shai Izraeli

Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel

Juliane Eilers

Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital, University of Heidelberg, Germany;Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany

Nina Vaezipour

Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital, University of Heidelberg, Germany;Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany

Renate Kirschner-Schwabe

Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany

Jana Hof

Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany;German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

Arend von Stackelberg

Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany

Martin Schrappe

Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany

Martin Stanulla

Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany;Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany

Martin Zimmermann

Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany

Rolf Koehler

Department of Human Genetics, University of Heidelberg, Germany

Smadar Avigad

Molecular Oncology, Felsenstein Medical Research Center and Pediatric Hematology Oncology, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel

Rupert Handgretinger

Children’s Hospital, University Hospital Tübingen, Germany

Viktoras Frismantas

Department of Oncology, University Children’s Hospital Zurich, Switzerland

Jean Pierre Bourquin

Department of Oncology, University Children’s Hospital Zurich, Switzerland

Beat Bornhauser

Department of Oncology, University Children’s Hospital Zurich, Switzerland

Jan O. Korbel

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany

Martina U. Muckenthaler

Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital, University of Heidelberg, Germany;Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany

Andreas E. Kulozik

Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital, University of Heidelberg, Germany;Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany