Evaluting the Efficacy of Inflammatory and Fibrotic Processes Correction in Patients with Chronic Viral Hepatitis C

Abstract

High levels of morbidity, deterioration in quality of life, increased mortality from complications of chronic liver disease causes socially significant medical problem. Search the inhibitory mechanisms of fibrogenesis processes is one of the important directions. This paper studied the effect of basic therapy (preparations of ursodeoxycholic acid, essential phospholipids, pentoxifylline, arginine hydrochloride) and a combination of basic therapy with autoсytokins on the parameters of the functional activity of the liver, endogenous intoxication, processes of fibrogenesis. The study involved 42 patients with chronic viral hepatitis C. The use of basic therapy and autoсytokins had a significant positive impact on the manifestation of cytolysis, cholestasis, the exchange of the extracellular matrix glycoprotein complexes, detoxification function of the liver and endotoxemia, pro- and antifibrogenic factors. The positive influence of the basic treatment on the studied parameters was less pronounced.

Keywords

• chronic viral hepatitis C
• cytolysis
• cholestasis
• fibrosis
• treatment