Nature Communications (Sep 2020)

FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples

  • Yao Xiao,
  • Xueqing Wang,
  • Hongjiu Zhang,
  • Peter J. Ulintz,
  • Hongyang Li,
  • Yuanfang Guan

DOI
https://doi.org/10.1038/s41467-020-18169-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Multiple algorithms exist for predicting heterogeneity and clonal architecture from the bulk sequencing of tumor tissue. Here, the authors report on an algorithm, FastClone, which was developed from a DREAM challenge and show that FastClone can accurately predict clonality in simulated data and data from colon cancer.