Nature Communications (Sep 2020)
FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
Abstract
Multiple algorithms exist for predicting heterogeneity and clonal architecture from the bulk sequencing of tumor tissue. Here, the authors report on an algorithm, FastClone, which was developed from a DREAM challenge and show that FastClone can accurately predict clonality in simulated data and data from colon cancer.