Nature Communications (Jan 2019)
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
- Andrew P. Morris,
- Thu H. Le,
- Haojia Wu,
- Artur Akbarov,
- Peter J. van der Most,
- Gibran Hemani,
- George Davey Smith,
- Anubha Mahajan,
- Kyle J. Gaulton,
- Girish N. Nadkarni,
- Adan Valladares-Salgado,
- Niels Wacher-Rodarte,
- Josyf C. Mychaleckyj,
- Nicole D. Dueker,
- Xiuqing Guo,
- Yang Hai,
- Jeffrey Haessler,
- Yoichiro Kamatani,
- Adrienne M. Stilp,
- Gu Zhu,
- James P. Cook,
- Johan Ärnlöv,
- Susan H. Blanton,
- Martin H. de Borst,
- Erwin P. Bottinger,
- Thomas A. Buchanan,
- Sylvia Cechova,
- Fadi J. Charchar,
- Pei-Lun Chu,
- Jeffrey Damman,
- James Eales,
- Ali G. Gharavi,
- Vilmantas Giedraitis,
- Andrew C. Heath,
- Eli Ipp,
- Krzysztof Kiryluk,
- Holly J. Kramer,
- Michiaki Kubo,
- Anders Larsson,
- Cecilia M. Lindgren,
- Yingchang Lu,
- Pamela A. F. Madden,
- Grant W. Montgomery,
- George J. Papanicolaou,
- Leslie J. Raffel,
- Ralph L. Sacco,
- Elena Sanchez,
- Holger Stark,
- Johan Sundstrom,
- Kent D. Taylor,
- Anny H. Xiang,
- Aleksandra Zivkovic,
- Lars Lind,
- Erik Ingelsson,
- Nicholas G. Martin,
- John B. Whitfield,
- Jianwen Cai,
- Cathy C. Laurie,
- Yukinori Okada,
- Koichi Matsuda,
- Charles Kooperberg,
- Yii-Der Ida Chen,
- Tatjana Rundek,
- Stephen S. Rich,
- Ruth J. F. Loos,
- Esteban J. Parra,
- Miguel Cruz,
- Jerome I. Rotter,
- Harold Snieder,
- Maciej Tomaszewski,
- Benjamin D. Humphreys,
- Nora Franceschini
Affiliations
- Andrew P. Morris
- Department of Biostatistics, University of Liverpool
- Thu H. Le
- Department of Medicine, Division of Nephrology, University of Virginia
- Haojia Wu
- Division of Nephrology, Washington University School of Medicine
- Artur Akbarov
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Peter J. van der Most
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Gibran Hemani
- MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
- George Davey Smith
- MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
- Anubha Mahajan
- Wellcome Centre for Human Genetics, University of Oxford
- Kyle J. Gaulton
- Department of Pediatrics, University of California, San Diego
- Girish N. Nadkarni
- Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Adan Valladares-Salgado
- Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
- Niels Wacher-Rodarte
- Unidad de Investigación Médica en Epidemiologia Clinica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
- Josyf C. Mychaleckyj
- Center for Public Health Genomics, University of Virginia School of Medicine
- Nicole D. Dueker
- John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine
- Xiuqing Guo
- Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Yang Hai
- Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Jeffrey Haessler
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Adrienne M. Stilp
- Department of Biostatistics, University of Washington
- Gu Zhu
- Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute
- James P. Cook
- Department of Biostatistics, University of Liverpool
- Johan Ärnlöv
- Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet
- Susan H. Blanton
- John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine
- Martin H. de Borst
- Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen
- Erwin P. Bottinger
- Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Thomas A. Buchanan
- Department of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of USC
- Sylvia Cechova
- Department of Medicine, Division of Nephrology, University of Virginia
- Fadi J. Charchar
- School of Health and Life Sciences, Federation University Australia
- Pei-Lun Chu
- Department of Internal Medicine, Fu Jen Catholic University Hospital, School of Medicine, Fu Jen Catholic University
- Jeffrey Damman
- Department of Pathology, Erasmus Medical Center Rotterdam
- James Eales
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Ali G. Gharavi
- Department of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University
- Vilmantas Giedraitis
- Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University
- Andrew C. Heath
- Department of Psychiatry, Washington University in St Louis
- Eli Ipp
- David Geffen School of Medicine, University of California Los Angeles
- Krzysztof Kiryluk
- Department of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University
- Holly J. Kramer
- Department of Medicine and Nephrology, Loyola University Medical Center
- Michiaki Kubo
- Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
- Anders Larsson
- Department of Medical Sciences, Clinical Epidemiology, Uppsala University
- Cecilia M. Lindgren
- Wellcome Centre for Human Genetics, University of Oxford
- Yingchang Lu
- Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Pamela A. F. Madden
- Department of Psychiatry, Washington University in St Louis
- Grant W. Montgomery
- Brisbane Institute for Molecular Bioscience, University of Queensland
- George J. Papanicolaou
- Epidemiology Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute
- Leslie J. Raffel
- Department of Pediatrics, Division of Genetic and Genomic Medicine, University of California
- Ralph L. Sacco
- Departments of Neurology and Public Health Sciences, Miller School of Medicine, University of Miami
- Elena Sanchez
- Department of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University
- Holger Stark
- Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf
- Johan Sundstrom
- Department of Medical Sciences, Clinical Epidemiology, Uppsala University
- Kent D. Taylor
- Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Anny H. Xiang
- Department of Research and Education, Kaiser Permanente Southern California
- Aleksandra Zivkovic
- Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf
- Lars Lind
- Department of Medical Sciences, Clinical Epidemiology, Uppsala University
- Erik Ingelsson
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Nicholas G. Martin
- Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute
- John B. Whitfield
- Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute
- Jianwen Cai
- Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill
- Cathy C. Laurie
- Department of Biostatistics, University of Washington
- Yukinori Okada
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Koichi Matsuda
- Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Yii-Der Ida Chen
- Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Tatjana Rundek
- Departments of Neurology and Public Health Sciences, Miller School of Medicine, University of Miami
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia School of Medicine
- Ruth J. F. Loos
- Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Esteban J. Parra
- Department of Anthropology, University of Toronto at Mississauga
- Miguel Cruz
- Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Maciej Tomaszewski
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Benjamin D. Humphreys
- Division of Nephrology, Washington University School of Medicine
- Nora Franceschini
- Department of Epidemiology, University of North Carolina
- DOI
- https://doi.org/10.1038/s41467-018-07867-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstream putative causal genes.
