Diabetes, Metabolic Syndrome and Obesity (Nov 2023)
The Role of PPARγ Gene Polymorphisms, Gut Microbiota in Type 2 Diabetes: Current Progress and Future Prospects
Abstract
Yi-Kun Zhao,1 Xiang-Dong Zhu,2 Rong Liu,1 Xia Yang,1 Yong-Lin Liang,1 Yan Wang2 1Department of Basic Medical College, Gansu University of Chinese Medicine, Lanzhou City, People’s Republic of China; 2Department of Traditional Chinese Medicine College, Ningxia Medical University, Yinchuan city, People’s Republic of ChinaCorrespondence: Yong-Lin Liang, Gansu University of Chinese Medicine, No. 35, Dingxi East Road, Chengguan District, Lanzhou City, Gansu, 730030, People’s Republic of China, Email [email protected] Yan Wang, Ningxia Medical University, No. 1160 Shengli Street, Xingqing District, Yinchuan City, Ningxia Hui Autonomous Region, 750004, People’s Republic of China, Tel +86-18153952736, Email [email protected]: Over the past decade, there has been a significant increase in studies investigating the relationship between the polymorphisms of the Peroxisome Proliferator-Activated Receptor gamma (PPARγ) gene and Type 2 Diabetes (T2D). PPARγ, a critical transcription factor, plays a central role in lipid metabolism, insulin resistance, and inflammatory response. Concurrently, the influence of gut microbiota on the development of T2D has gained increasing attention, especially their role in affecting host metabolism, such as lipid metabolism and the PPARγ signaling pathway. This review provides a comprehensive analysis of recent studies on PPARγ gene polymorphisms and their association with T2D, with a specific emphasis on the implications of gut microbiota and their interaction with PPARγ pathways. We also discuss the potential of manipulating gut microbiota and targeting PPARγ gene polymorphisms in T2D management. By deepening our understanding of these relationships, we aim to pave the way for novel preventative and therapeutic strategies for T2D.Keywords: PPARγ, T2D, lipid metabolism, insulin resistance, gut microbiota
