ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS

Abstract

It was established that a changes of antibody production and reaction of delayed—type hypersensitivity at the local immune response to thymus-dependent antigen were opposite in rats with varying severity of experimental thyrotoxicosis — stimulation under a mild form of thyrotoxicosis and depression under more severe form. The increase in glucocorticoid level may be involved in the mechanism of immunosuppression under severe form thyrotoxicosis. The administration of agonist or antagonist of beta-adrenoceptors to animals with thyrotoxicosis led to the significant modification of changes of an immune response parameters, that confirms the participation of an increase in the sensitivity to beta-adrenergic regulation of immune system cells in immunomodulation under thyrotoxicosis.

Keywords

• experimental thyrotoxicosis
• adrenoceptors
• the immune response