Prognostic factors of the efficiency of obtaining the autologous precursor cells of hemopoiesis for further transplantation after large-dose chemotherapy: review of literature and the authors' data

Abstract

To obtain a sufficient number of hemopoietic progenitor cells (HPCs) for a rapid and stable recovery of hematopoiesis is one of the major conditions for safe high-dose chemotherapy. The paper analyses the current approaches to mobilizing and collecting HPCs, as well as the factors influencing their efficiency. By using their own large material (264 patients who had undergone mobilizing procedures), the authors have shown that none of predictors (age, a history of multiple courses of chemotherapy, peripheral blood levels of CD34+ cells at sampling, etc.) may identify patients in whom peripheral blood HPCs cannot be certainly ineffectively collected. At the same time, combined mobilization with myelostimulating factors (granulocyte, granulocytemacrophage colony-stimulating factors) and cytostatics (high-dose cyclophosphamide) yield the greatest quantities of HPCs from peripheral blood in patients with solid tumors and multiple myeloma.

Keywords

• hemopoietic precursor cells
• large-dose chemotherapy
• peripheral blood levels of hemopoietic precursor cells
• granulocytic
• granulocytemacrophage colony-stimulating factors