Nature Communications (Aug 2021)

Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans

  • Yisrael Rappaport,
  • Hanna Achache,
  • Roni Falk,
  • Omer Murik,
  • Oren Ram,
  • Yonatan B. Tzur

DOI
https://doi.org/10.1038/s41467-021-24815-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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During meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex chromosomes promotes silencing.