Systemic reactogenicity following homologues and heterologous prime-boost AZD1222 and BNT162b2 COVID-19 vaccination of 2862 healthcare workers compared with an unvaccinated population
Sorosh Tabatabaeifar,
Jesper M. Vestergaard,
Else T. Würtz,
Karoline K. Hansen,
Kent J. Nielsen,
Vivi Schlünssen,
Henrik A. Kolstad
Affiliations
Sorosh Tabatabaeifar
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark; Corresponding author at: Department of Occupational Medicine, Aarhus University Hospital, Palle Juul-Jensens, Boulevard 99, DK-8200 Aarhus N, Denmark.
Jesper M. Vestergaard
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark
Else T. Würtz
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark
Karoline K. Hansen
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark
Kent J. Nielsen
Department of Occupational Medicine, Danish Ramazzini Centre, Goedstrup Hospital, Herning, Denmark
Vivi Schlünssen
Department of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
Henrik A. Kolstad
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
During spring 2021, AZD1222 and BNT162b2 were used as prime and BNT162b2 as booster COVID-19 vaccines in Denmark. We obtained self-reported information on systemic reactogenicity day-by-day during two weeks for 2862 healthcare workers vaccinated with heterologous AZD1222 + BNT162b2 or homologous BNT162b2 + BNT162b2 regimens and compared prevalences of symptoms with unvaccinated healthcare workers. We found comparable systemic reactogenicity during the first week in the two vaccine regimens and no reactogenicity during the second week. Most of the symptoms returned to a level equal to the control population four days after booster vaccination.
