IMPACT OF MODERN ANTIHYPERTENSION MEDICATIONS ON THE CENTRAL PRESSURE AND ARTERIAL RIGIDITY

Abstract

Aim. To study the impact of 16-week pharmacotherapy with а1,в- adrenoblocker carvedilol (С) on the parameters of pressure and vascular rigidity in arteries of different size in 1-2 grade arterial hypertension (AH) patients.Material and methods. Totally 36 patients studied with AH of 1-2 grade at the age 49,9±9,4 y.o. We analyzed structural-functional parameters of the vessel wall, using methods of 24-hour blood pressure monitoring and assessment of the rigidity by Vasera-1000 equipment and current- related vasodilation (CRVD) in test with post occlusion reactive hyperemia by ultrasound device My Lab 90. All patients received С during 16 weeks treatment.Results. At the background of pharmacotherapy, there was significant dynamic of aortic pressure by the data of 24-hour monitoring. There was a decrease of the mean 24-hour values of the central velocity of pulse wave (PWV) by 5,2% (p<0,01) with the absence of adverse influence on reflected pulse wave. By the data of volume-related sphygmography there was significant decrease of PWV in aorta by 13%, in mostly elastic arteries by 6% and muscular type — by 14% (p<0,05). While studying CRVD in post occlusion reactive hyperemia test the С therapy has also supported the improvement of endothelial function. Conclusion. 16-week С therapy, except BP normalization in various caliber arteries, improved structural-functional properties of the vessel wall.

Keywords

• артериальная гипертензия
• в-адреноблокаторы
• центральное (аортальное) давление
• жесткость артерий