Clinical, Cosmetic and Investigational Dermatology (Nov 2023)
Association of Complete Blood Cell Count-Derived Inflammatory Biomarkers with Psoriasis and Mortality
Abstract
Yang Zhao,1,2 Xu Tong Yang,1 Yan Ping Bai,3 Lin Feng Li2 1Department of Dermatology, Daxing Teaching Hospital, Capital Medical University, Beijing, 102600, People’s Republic of China; 2Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 3Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of ChinaCorrespondence: Lin Feng Li, Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, 95 Yong an Road, Xicheng District, Beijing, 100050, People’s Republic of China, Email [email protected] and Aim: Psoriasis is a persistent inflammatory disorder that affects 3% of the population and is associated with cardiovascular diseases. Therefore, this study aimed to investigate the correlations between complete blood cell count (CBC)-derived inflammatory biomarkers, psoriasis prevalence, and all-cause mortality.Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) spanning 2003– 2006 and 2009– 2014. Mortality data up to December 31, 2019 were obtained using the National Death Index. The following CBC-derived inflammatory biomarkers were examined: neutrophil/lymphocyte ratio (NLR), neutrophil/(white blood cells ˗ neutrophils) ratio (dNLR), monocyte count/lymphocyte ratio (MLR), (neutrophil + monocyte)/lymphocyte ratio (NMLR), platelet/lymphocyte ratio (PLR), and systemic inflammatory response index (SIRI). Weighted logistic and Cox regression analyses were used to calculate odds ratios, hazard ratios, and the corresponding 95% confidence intervals. Additionally, the prognostic value of the inflammatory indicators was assessed and ranked using the random survival forest approach.Results: In total, data from 21,431 participants with average age of 45.02 ± 0.27 years (49.51% male) were included in the study, among which 600 participants were positive for psoriasis (prevalence rate, 2.80%). Additionally, 79 all-cause deaths were recorded during a median follow-up period of 8.83 (6.67– 11.00) years. Moreover, NLR, dNLR, NMLR, PLR, and SIRI were positively associated with the prevalence of psoriasis. Furthermore, MLR, NMLR, and SIRI were positively correlated with all-cause mortality in patients with psoriasis, with NMLR being the most valuable predictor of all-cause mortality.Conclusion: CBC-derived inflammatory biomarkers were associated with psoriasis prevalence, NMLR, SIRI, and MLR values were associated with all-cause mortality in patients with psoriasis. Overall, assessment of these CBC-derived indicators may serve as a simple method for screening high-risk individuals among patients with psoriasis.Keywords: association, biomarker, inflammatory, NHANES, psoriasis
