Therapeutic Properties of Vanadium Complexes

Abeer A. Sharfalddin; Inas M. Al-Younis; Hamdoon A. Mohammed; Manel Dhahri; Fouzi Mouffouk; Hijazi Abu Ali; Md. Jamir Anwar; Kamal A. Qureshi; Mostafa A. Hussien; Mawadda Alghrably; Mariusz Jaremko; Noura Alasmael; Joanna Izabela Lachowicz; Abdul-Hamid Emwas

doi:10.3390/inorganics10120244

Inorganics (Dec 2022)

Therapeutic Properties of Vanadium Complexes

Abeer A. Sharfalddin,
Inas M. Al-Younis,
Hamdoon A. Mohammed,
Manel Dhahri,
Fouzi Mouffouk,
Hijazi Abu Ali,
Md. Jamir Anwar,
Kamal A. Qureshi,
Mostafa A. Hussien,
Mawadda Alghrably,
Mariusz Jaremko,
Noura Alasmael,
Joanna Izabela Lachowicz,
Abdul-Hamid Emwas

Affiliations

Abeer A. Sharfalddin: Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Inas M. Al-Younis: Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia
Hamdoon A. Mohammed: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia
Manel Dhahri: Biology Department, Faculty of Science Yanbu, Taibah University, Yanbu 46423, Saudi Arabia
Fouzi Mouffouk: Department of Chemistry, Kuwait University, P.O. Box 5969, Kuwait City 13060, Kuwait
Hijazi Abu Ali: Department Chemistry, Faculty of Science, Birzeit University, Birzeit P.O. Box 14, Palestine
Md. Jamir Anwar: Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Unaizah 51911, Saudi Arabia
Kamal A. Qureshi: Department of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, Unaizah 51911, Saudi Arabia
Mostafa A. Hussien: Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Mawadda Alghrably: Smart-Health Initiative (SHI), Red Sea Research Center (RSRC), Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955, Saudi Arabia
Mariusz Jaremko: Smart-Health Initiative (SHI), Red Sea Research Center (RSRC), Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955, Saudi Arabia
Noura Alasmael: Physical Science and Engineering Division (PSE), King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia
Joanna Izabela Lachowicz: Department of Medical Sciences and Public Health, Università di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Abdul-Hamid Emwas: Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia

DOI: https://doi.org/10.3390/inorganics10120244
Journal volume & issue: Vol. 10, no. 12
p. 244

Abstract

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Vanadium is a hard, silver-grey transition metal found in at least 60 minerals and fossil fuel deposits. Its oxide and other vanadium salts are toxic to humans, but the toxic effects depend on the vanadium form, dose, exposure duration, and route of intoxication. Vanadium is used by some life forms as an active center in enzymes, such as the vanadium bromoperoxidase of ocean algae and nitrogenases of bacteria. The structure and biochemistry of vanadate resemble those of phosphate, hence vanadate can be regarded as a phosphate competitor in a variety of biochemical enzymes such as kinases and phosphatases. In this review, we describe the biochemical pathways regulated by vanadium compounds and their potential therapeutic benefits for a range of disorders including type 2 diabetes, cancer, cardiovascular disease, and microbial pathology.

Published in Inorganics

ISSN: 2304-6740 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Inorganic chemistry
Website: http://www.mdpi.com/journal/Inorganics

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