Communications Biology (Jan 2022)

Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice

  • Yasuhiro Nakano,
  • Sachie Nakao,
  • Minako Sueoka,
  • Daigo Kasahara,
  • Yuri Tanno,
  • Hideaki Sumiyoshi,
  • Tohru Itoh,
  • Atsushi Miyajima,
  • Katsuto Hozumi,
  • Yutaka Inagaki

DOI
https://doi.org/10.1038/s42003-022-03013-8
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 10

Abstract

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Dll4/Notch1 signal promotes the progression of HCC, while Jag1/Notch2 signal antagonistically suppresses it in murine chemical hepatocarcinogenesis. Nakano et al. report that two distinct Notch signals regulate the progression of hepatocellular carcinoma (HCC) using tissue specific loss of function mouse mutants. They find Dll4/Notch1 signal promotes HCC progression, while the Jag1/Notch2 signal antagonistically suppresses it.