Nature Communications (Aug 2020)

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

  • Jincheng Wang,
  • Jiajia Wang,
  • Lijun Yang,
  • Chuntao Zhao,
  • Laiman Natalie Wu,
  • Lingli Xu,
  • Feng Zhang,
  • Qinjie Weng,
  • Michael Wegner,
  • Q. Richard Lu

DOI
https://doi.org/10.1038/s41467-020-17955-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies. Here the authors describe a critical role of CCCTC-binding factor (CTCF)-dependent chromatin reorganization in peripheral myelination and myelin regeneration after injury.