Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France; Department of Clinical Science, University of Torino, Torino, Italy; Eye Clinic, University of Torino, Torino, Italy
Hugo Charles Messance
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France
Sébastien Augustin
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France
Elisa Dominguez
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France
Sophie Lavalette
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France
Valérie Forster
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France
Shulong Justin Hu
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France
Lourdes Siquieros
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France
Cheryl Mae Craft
Mary D. Allen Laboratory for Vision Research, Keck School of Medicine of the University of Southern California, Los Angeles, United States; University of Southern California Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, United States; Department of Ophthalmology and Cell, Keck School of Medicine of the University of Southern California, Los Angeles, United States; Department of Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, United States
José-Alain Sahel
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, Paris, France
Ramin Tadayoni
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France; Department of Ophthalmology, Hôpital Lariboisièr, Paris, France
Michel Paques
Sorbonne Universités, UPMC University Paris 06, INSERM, CNRS, Paris, France; Institut de la Vision, Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, Paris, France
Photo-transduction in cone segments (CS) is crucial for high acuity daytime vision. For ill-defined reasons, CS degenerate in retinitis pigmentosa (RP) and in the transitional zone (TZ) of atrophic zones (AZ), which characterize geographic atrophy (GA). Our experiments confirm the loss of cone segments (CS) in the TZ of patients with GA and show their association with subretinal CD14+mononuclear phagocyte (MP) infiltration that is also reported in RP. Using human and mouse MPs in vitro and inflammation-prone Cx3cr1GFP/GFP mice in vivo, we demonstrate that MP-derived IL-1β leads to severe CS degeneration. Our results strongly suggest that subretinal MP accumulation participates in the observed pathological photoreceptor changes in these diseases. Inhibiting subretinal MP accumulation or Il-1β might protect the CS and help preserve high acuity daytime vision in conditions characterized by subretinal inflammation, such as AMD and RP.
