Design and evaluation of a metronidazole central core matrix tablet

Abstract

In this paper, a study of different concentration of HPMC K 15 M exerts influence on the drug release process from a new controlled drug delivery system has been realized in order to obtain a constant release rate during a prolonged period of time, for a programmed drug release. The drug release profiles obtained for the different batches have shown an interesting relationship between the particle size of the channeling agent used and the length of different operational periods.

Keywords

• Matrix
• Metronidazole
• Controlled drug delivery system
• Tablets