The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism

• Elena Arutyunova,
• Alexandr Belovodskiy,
• Pu Chen,
• Muhammad Bashir Khan,
• Michael Joyce,
• Holly Saffran,
• Jimmy Lu,
• Zoe Turner,
• Bing Bai,
• Tess Lamer,
• Howard S. Young,
• John C. Vederas,
• D. Lorne Tyrrell,
• M. Joanne Lemieux,
• James A. Nieman

Affiliations

Elena Arutyunova

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

Alexandr Belovodskiy

Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada

Pu Chen

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

Muhammad Bashir Khan

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

Michael Joyce

Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada

Holly Saffran

Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada

Jimmy Lu

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

Zoe Turner

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

Bing Bai

Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada

Tess Lamer

Department of Chemistry, University of Alberta, Edmonton, AB, Canada

Howard S. Young

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

John C. Vederas

Department of Chemistry, University of Alberta, Edmonton, AB, Canada

D. Lorne Tyrrell

Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada

M. Joanne Lemieux

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

James A. Nieman

Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada