Journal of Clinical Medicine (Sep 2021)
Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu
- María José García,
- Montserrat Rivero,
- José Miranda-Bautista,
- Iria Bastón-Rey,
- Francisco Mesonero,
- Eduardo Leo-Carnerero,
- Diego Casas-Deza,
- Carmen Cagigas Fernández,
- Albert Martin-Cardona,
- Ismael El Hajra,
- Nerea Hernández-Aretxabaleta,
- Isabel Pérez-Martínez,
- Esteban Fuentes-Valenzuela,
- Nuria Jiménez,
- Cristina Rubín de Célix,
- Ana Gutiérrez,
- Cristina Suárez Ferrer,
- José María Huguet,
- Agnes Fernández-Clotet,
- María González-Vivó,
- Blanca Del Val,
- Jesús Castro-Poceiro,
- Luigi Melcarne,
- Carmen Dueñas,
- Marta Izquierdo,
- David Monfort,
- Abdel Bouhmidi,
- Patricia Ramírez De la Piscina,
- Eva Romero,
- Gema Molina,
- Jaime Zorrilla,
- Cristina Calvino-Suárez,
- Eugenia Sánchez,
- Andrea Nuñez,
- Olivia Sierra,
- Beatriz Castro,
- Yamile Zabana,
- Irene González-Partida,
- Saioa De la Maza,
- Andrés Castaño,
- Rodrigo Nájera-Muñoz,
- Luis Sánchez-Guillén,
- Micaela Riat Castro,
- José Luis Rueda,
- José Manuel Benítez,
- Pedro Delgado-Guillena,
- Carlos Tardillo,
- Elena Peña,
- Santiago Frago-Larramona,
- María Carmen Rodríguez-Grau,
- Rocío Plaza,
- Pablo Pérez-Galindo,
- Jesús Martínez-Cadilla,
- Luis Menchén,
- Manuel Barreiro-De Acosta,
- Rubén Sánchez-Aldehuelo,
- María Dolores De la Cruz,
- Luis Javier Lamuela,
- Ignacio Marín,
- Laura Nieto-García,
- Antonio López-San Román,
- José Manuel Herrera,
- María Chaparro,
- Javier P. Gisbert,
- on behalf of the Young Group of GETECCU
Affiliations
- María José García
- Gastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, Spain
- Montserrat Rivero
- Gastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, Spain
- José Miranda-Bautista
- Gastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, Spain
- Iria Bastón-Rey
- Gastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain
- Francisco Mesonero
- Gastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- Eduardo Leo-Carnerero
- Gastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
- Diego Casas-Deza
- Gastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, Spain
- Carmen Cagigas Fernández
- Colorectal Unit, Department of General and Digestive Surgery, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
- Albert Martin-Cardona
- Gastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, Spain
- Ismael El Hajra
- Gastroenterology Department, Hospital Universitario Puerta de Hierro, 28220 Majadahonda, Spain
- Nerea Hernández-Aretxabaleta
- Gastroenterology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain
- Isabel Pérez-Martínez
- Department of Gastroenterology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
- Esteban Fuentes-Valenzuela
- Gastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, Spain
- Nuria Jiménez
- Gastroenterology Department, Hospital General Universitario de Elche, 03203 Alicante, Spain
- Cristina Rubín de Célix
- Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Ana Gutiérrez
- Gastroenterology Department, Hospital General de Alicante, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, Spain
- Cristina Suárez Ferrer
- Gastroenterology Department, Hospital Universitario La Paz, 28046 Madrid, Spain
- José María Huguet
- Gastroenterology Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain
- Agnes Fernández-Clotet
- Gastroenterology Department, Hospital Clinic of Barcelona, 08036 Barcelona, Spain
- María González-Vivó
- Gastroenterology Department, Hospital del Mar, 08003 Barcelona, Spain
- Blanca Del Val
- Gastroenterology Department, Hospital Rafael Méndez, 30817 Lorca, Spain
- Jesús Castro-Poceiro
- Gastroenterology Department, Hospital Sant Joan Despí-Moisès Broggi, 08970 Barcelona, Spain
- Luigi Melcarne
- Gastroenterology Department, Hospital Universitari Parc Taulí, Sabadell, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08208 Barcelona, Spain
- Carmen Dueñas
- Gastroenterology Department, Hospital Universitario de Cáceres, 10003 Cáceres, Spain
- Marta Izquierdo
- Gastroenterology Department, Hospital Universitario de Cabueñes, 33203 Gijón, Spain
- David Monfort
- Gastroenterology Department, Consorcio Sanitario de Terrasa, 08227 Barcelona, Spain
- Abdel Bouhmidi
- Gastroenterology Department, Hospital de Santa Bárbara, 13500 Puertollano, Spain
- Patricia Ramírez De la Piscina
- Gastroenterology Department, Hospital Universitario Vitoria-Gastéiz, 01002 Vitoria, Spain
- Eva Romero
- Gastroenterology Department, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain
- Gema Molina
- Gastroenterology Department, Hospital Arquitecto Marcide, 15405 Ferrol, Spain
- Jaime Zorrilla
- Department of Colorectal and Gastrointestinal Surgery, Hospital Universitario Gregorio Marañón, 28009 Madrid, Spain
- Cristina Calvino-Suárez
- Gastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain
- Eugenia Sánchez
- Gastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- Andrea Nuñez
- Gastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
- Olivia Sierra
- Gastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, Spain
- Beatriz Castro
- Gastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, Spain
- Yamile Zabana
- Gastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, Spain
- Irene González-Partida
- Gastroenterology Department, Hospital Universitario Puerta de Hierro, 28220 Majadahonda, Spain
- Saioa De la Maza
- Gastroenterology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain
- Andrés Castaño
- Department of Gastroenterology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
- Rodrigo Nájera-Muñoz
- Gastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, Spain
- Luis Sánchez-Guillén
- Department of Colorectal and Gastrointestinal Surgery, Hospital General Universitario de Elche, 03203 Alicante, Spain
- Micaela Riat Castro
- Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- José Luis Rueda
- Gastroenterology Department, Hospital Universitario La Paz, 28046 Madrid, Spain
- José Manuel Benítez
- Gastroenterology Department, Hospital Reina Sofía, IMIBIC, 14004 Córdoba, Spain
- Pedro Delgado-Guillena
- Gastroenterology Department, Hospital General de Granollers, 08042 Granollers, Spain
- Carlos Tardillo
- Gastroenterology Department, Hospital Nuestra Señora de la Candelaria, 38010 Tenerife, Spain
- Elena Peña
- Gastroenterology Department, Hospital Royo Villanova, 50007 Zaragoza, Spain
- Santiago Frago-Larramona
- Gastroenterology Department, Complejo Hospitalario de Soria, 42005 Soria, Spain
- María Carmen Rodríguez-Grau
- Gastroenterology Department, Hospital Universitario de Henares, 28002 Coslada, Spain
- Rocío Plaza
- Gastroenterology Department, Hospital Universitario Infanta Leonor, Vallecas, 28031 Madrid, Spain
- Pablo Pérez-Galindo
- Gastroenterology Department, Complejo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, Spain
- Jesús Martínez-Cadilla
- Gastroenterology Department, Hospital Álvaro Cunqueiro de Vigo, 36312 Vigo, Spain
- Luis Menchén
- Gastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, Spain
- Manuel Barreiro-De Acosta
- Gastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain
- Rubén Sánchez-Aldehuelo
- Gastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- María Dolores De la Cruz
- Gastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
- Luis Javier Lamuela
- Gastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, Spain
- Ignacio Marín
- Gastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, Spain
- Laura Nieto-García
- Gastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain
- Antonio López-San Román
- Gastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- José Manuel Herrera
- Gastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
- María Chaparro
- Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Javier P. Gisbert
- Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- on behalf of the Young Group of GETECCU
- DOI
- https://doi.org/10.3390/jcm10194402
- Journal volume & issue
-
Vol. 10,
no. 19
p. 4402
Abstract
Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections.
Keywords