MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

Barry Slaff; Caleb M. Radens; Paul Jewell; Anupama Jha; Nicholas F. Lahens; Gregory R. Grant; Andrei Thomas-Tikhonenko; Kristen W. Lynch; Yoseph Barash

doi:10.1038/s41467-021-23608-9

Nature Communications (Jun 2021)

MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

Barry Slaff,
Caleb M. Radens,
Paul Jewell,
Anupama Jha,
Nicholas F. Lahens,
Gregory R. Grant,
Andrei Thomas-Tikhonenko,
Kristen W. Lynch,
Yoseph Barash

Affiliations

Barry Slaff: Department of Computer and Information Sciences, School of Engineering, University of Pennsylvania
Caleb M. Radens: Department of Genetics, Perelman School of Medicine, University of Pennsylvania
Paul Jewell: Department of Genetics, Perelman School of Medicine, University of Pennsylvania
Anupama Jha: Department of Computer and Information Sciences, School of Engineering, University of Pennsylvania
Nicholas F. Lahens: Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania
Gregory R. Grant: Department of Genetics, Perelman School of Medicine, University of Pennsylvania
Andrei Thomas-Tikhonenko: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
Kristen W. Lynch: Department of Genetics, Perelman School of Medicine, University of Pennsylvania
Yoseph Barash: Department of Computer and Information Sciences, School of Engineering, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-021-23608-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Confounding factors on gene expression analysis can be analyzed by several existing tools. Here the authors develop an algorithm called MOCCASIN to correct the effect of known and unknown confounders on RNA splicing quantification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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