Nature Communications (Apr 2021)
A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia
- T. Roderick Docking,
- Jeremy D. K. Parker,
- Martin Jädersten,
- Gerben Duns,
- Linda Chang,
- Jihong Jiang,
- Jessica A. Pilsworth,
- Lucas A. Swanson,
- Simon K. Chan,
- Readman Chiu,
- Ka Ming Nip,
- Samantha Mar,
- Angela Mo,
- Xuan Wang,
- Sergio Martinez-Høyer,
- Ryan J. Stubbins,
- Karen L. Mungall,
- Andrew J. Mungall,
- Richard A. Moore,
- Steven J. M. Jones,
- İnanç Birol,
- Marco A. Marra,
- Donna Hogge,
- Aly Karsan
Affiliations
- T. Roderick Docking
- Experimental Medicine Program, Department of Medicine, University of British Columbia
- Jeremy D. K. Parker
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Martin Jädersten
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Gerben Duns
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Linda Chang
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Jihong Jiang
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Jessica A. Pilsworth
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Lucas A. Swanson
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Simon K. Chan
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Readman Chiu
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Ka Ming Nip
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Samantha Mar
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Angela Mo
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Xuan Wang
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Sergio Martinez-Høyer
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Ryan J. Stubbins
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Karen L. Mungall
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Andrew J. Mungall
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Richard A. Moore
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Steven J. M. Jones
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- İnanç Birol
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Marco A. Marra
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Donna Hogge
- Leukemia Bone Marrow Transplant Program of BC, Vancouver General Hospital
- Aly Karsan
- Experimental Medicine Program, Department of Medicine, University of British Columbia
- DOI
- https://doi.org/10.1038/s41467-021-22625-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Several genomic features have been found for acute myeloid leukaemia (AML) but targeted clinical genetic testing fails to predict prognosis. Here, the authors generate an AML prognostic score from RNA-seq data of patients, which successfully stratifies AML patients and which may provide guidance for therapeutic strategies.
