Nature Communications (Jun 2019)
A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles
- Hao Zheng,
- Zhitao Zhang,
- Su Jiang,
- Biao Yan,
- Xiang Shi,
- Yuanting Xie,
- Xu Huang,
- Zeyang Yu,
- Huizhu Liu,
- Shijun Weng,
- Arto Nurmikko,
- Yuqiu Zhang,
- Huisheng Peng,
- Wendong Xu,
- Jiayi Zhang
Affiliations
- Hao Zheng
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Zhitao Zhang
- State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University
- Su Jiang
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Biao Yan
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Xiang Shi
- State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University
- Yuanting Xie
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Xu Huang
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Zeyang Yu
- School of Engineering, Brown University
- Huizhu Liu
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Shijun Weng
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Arto Nurmikko
- School of Engineering, Brown University
- Yuqiu Zhang
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Huisheng Peng
- State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University
- Wendong Xu
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Jiayi Zhang
- State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Institutes of Brain Science, Department of Hand Surgery, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- DOI
- https://doi.org/10.1038/s41467-019-10418-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Optogenetic stimulation of damaged peripheral nerves has advantages over electrical stimulation but it’s limited to single-site stimulation. Here the authors develop a spiral-shaped LED implant for precise optogenetic stimulation of peripheral nerve bundles at multiple sites and use it to induce distinct limb movements in mice.
