PLoS ONE (Jan 2019)

Analysis of predictive factors for R0 resection and immediate bleeding of cold snare polypectomy in colonoscopy.

  • Tomonori Aoki,
  • Shuntaro Yoshida,
  • Hiroyuki Abe,
  • Satoshi Ono,
  • Ayako Nakada,
  • Yumiko Ota,
  • Akiko Narita,
  • Takeshi Yoshikawa,
  • Hiroto Kinoshita,
  • Yosuke Tsuji,
  • Atsuo Yamada,
  • Mitsuhiro Fujishiro,
  • Yoshihiro Hirata,
  • Masashi Fukayama,
  • Kazuhiko Koike

DOI
https://doi.org/10.1371/journal.pone.0213281
Journal volume & issue
Vol. 14, no. 3
p. e0213281

Abstract

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BACKGROUND:Factors associated with efficacy and safety of cold snare polypectomy (CSP) are not well established. The aim is to elucidate the predictors of R0 resection and immediate bleeding of CSP. METHODS:We retrospectively reviewed a database of patients who underwent CSP for subcentimetric polyps at the University of Tokyo Hospital in Japan. Using the data regarding the characteristics of patients and polyps, such as location, size, and macroscopic appearance; use of narrow band imaging with magnification (NBI-M); and endoscopists' experience, we revealed the predictive factors associated with R0 resection and immediate post-CSP bleeding by univariate and multivariate analyses. RESULTS:In total, 399 polyps, in 200 patients without antithrombotics, were removed. Failure of tissue retrieval was noted in 4% of resected lesions. There was no intramucosal carcinoma observed. The overall rate of R0 resection was 46%. Multivariate analysis elucidated that the observation of the polyp with NBI-M was an independent predictor associated with R0 resection (odds ratio [OR] 1.90; p = 0.024). Although immediate post-CSP bleeding occurred in 19 polyps (4.8%), no delayed bleeding or perforation was observed. Multivariate analysis revealed protruded lesion as an independent risk factor for immediate bleeding (OR 3.54; p = 0.018). CONCLUSIONS:A higher rate of R0 resection with CSP can be achieved by performing colonoscopy with NBI-M, than with white-light imaging. Macroscopic protruding appearance of a polyp is a risk factor for immediate bleeding.