Review Artikel : Respon Antibodi terhadap Protein Permukaan Merozoit Plasmodium Falciparum dalam Penentuan Transmisi Malaria

Abstract

Malaria is one of the issues most important public health around the world. Malaria is the leading cause of death and disease in developing countries, children and pregnant women are the group most vulnerable to infection. Transmission measurements made as the evaluation of malaria control programs. Some epidemiological models ofmalaria that has been develope is useful in describing the transmission of malaria is based on several factors.In this review described briefly regarding the transmission of malaria, measurement methods, especially measurement serologically transmission, serological markers used, as well as anti-malarial antibody response that appears on these serological markers.There are three main methods of measuring the transmission of malaria, namely Entomological Inoculation Rates (EIR),Vectorial Capacity (VC) and Case Basic Reproduction Rate (Ro). malaria transmission measurement can also be done by using serological markers. Serological marker that has been proven can be used to estimate the malaria transmission for long periods or being in the endemic areas is the MSP-1, MSP-2, and AMA-1.Antibody responses may reflect the occurrence of malaria transmission due to higher antibody responses correlated positively with exposure to Plasmodium infection. Serological parameters has advantages over other measurement methods to determine the endemicity, because the antibody response can persist for several months to severalyears after infection.

Keywords

• antibody anti merozoit
• malarial transmission
• serological marker
• Plasmodium falciparum