Nature Communications (Aug 2022)
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
- Mithu Baidya,
- Madhu Chaturvedi,
- Hemlata Dwivedi-Agnihotri,
- Ashutosh Ranjan,
- Dominic Devost,
- Yoon Namkung,
- Tomasz Maciej Stepniewski,
- Shubhi Pandey,
- Minakshi Baruah,
- Bhanupriya Panigrahi,
- Parishmita Sarma,
- Manish K. Yadav,
- Jagannath Maharana,
- Ramanuj Banerjee,
- Kouki Kawakami,
- Asuka Inoue,
- Jana Selent,
- Stéphane A. Laporte,
- Terence E. Hébert,
- Arun K. Shukla
Affiliations
- Mithu Baidya
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Madhu Chaturvedi
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Hemlata Dwivedi-Agnihotri
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Ashutosh Ranjan
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Dominic Devost
- Department of Pharmacology and Therapeutics, McGill University
- Yoon Namkung
- Department of Medicine, McGill University Health Center, McGill University
- Tomasz Maciej Stepniewski
- Research Program on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM)
- Shubhi Pandey
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Minakshi Baruah
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Bhanupriya Panigrahi
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Parishmita Sarma
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Manish K. Yadav
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Jagannath Maharana
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Ramanuj Banerjee
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- Kouki Kawakami
- Graduate School of Pharmaceutical Sciences, Tohoku University
- Asuka Inoue
- Graduate School of Pharmaceutical Sciences, Tohoku University
- Jana Selent
- Research Program on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM)
- Stéphane A. Laporte
- Department of Pharmacology and Therapeutics, McGill University
- Terence E. Hébert
- Department of Pharmacology and Therapeutics, McGill University
- Arun K. Shukla
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-022-32386-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.
