Bone metastases in hepatoblastoma, an unusual presentation. Case report and review of the literature

Abstract

Primary liver tumors are rare in childhood. Hepatoblastoma is the most prevalent and has a variable clinical presentation. The initial approach requires clinical suspicion, histopathological confirmation, and measurement of AFP levels, in addition to PRETEXT staging by abdominal computed tomography. PET-CT is useful in metastatic disease for diagnosis and evaluation of therapeutic response. Pulmonary metastases at the time of diagnosis are frequent, while bone metastases are rare. We present the case of an infant with a history of metastatic hepatoblastoma, multiple relapses, and poor response to multimodal management. The patient had bone metastases demonstrated by PET-CT imaging.

Keywords

• Hepatoblastoma
• Neoplasm staging
• Alpha-fetoprotein
• Neoplasm metastasis
• Bone
• Therapeutics