mBio
(Feb 2021)
Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract
Sabrina I. Green,
Carmen Gu Liu,
Xue Yu,
Shelley Gibson,
Wilhem Salmen,
Anubama Rajan,
Hannah E. Carter,
Justin R. Clark,
Xuezheng Song,
Robert F. Ramig,
Barbara W. Trautner,
Heidi B. Kaplan,
Anthony W. Maresso
Affiliations
Sabrina I. Green
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Carmen Gu Liu
ORCiD Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Xue Yu
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Shelley Gibson
Department of Human Genetics, Baylor College of Medicine, Houston, Texas, USA
Wilhem Salmen
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Anubama Rajan
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Hannah E. Carter
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Justin R. Clark
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Xuezheng Song
Department of Biochemistry, Emory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, Georgia, USA
Robert F. Ramig
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Barbara W. Trautner
Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas, USA
Heidi B. Kaplan
Department of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA
Anthony W. Maresso
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
DOI
https://doi.org/10.1128/mBio.03474-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Invasive pathobionts or microbes capable of causing disease can reside deep within the mucosal epithelium of our gastrointestinal tract. Targeted effective antibacterial therapies are needed to combat these disease-causing organisms, many of which may be multidrug resistant.
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