Clinical value of serum markers of type 2 diabetes mellitus complicated by chronic periodontitis

Abstract

Objective To investigate the relation between serum markers, the degree of lesions and the active peri⁃ od of chronic periodontitis in patients with type 2 diabetes mellitus. Methods A total of 595 patients with type 2 dia⁃ betes mellitus were selected, and oral examinations and laboratory tests were conducted. The patients were divided into a periodontally healthy group mild, moderate and severe periodontitis groups depending on the diagnostic criteria for chronic periodontitis. The patients were also divided into periodontally healthy, resting and active groups depending on the diagnostic criteria of the active period. The relationships between serum biochemical indices, the degree of lesions and chronic periodontitis activity were analyzed. Results The prevalence of chronic periodontitis in patients with type 2 diabetes was 74.6% , and the proportions of patients with mild, moderate, and severe chronic periodontitis were 44.9%, 16.1% and 13.6%, respectively. The composite ratio of active periodontal chronic periodontitis was 33.1%. Com⁃pared with the patients in the control group, the fasting plasma glucose and HbA1c levels were more poorly controlled in the type 2 diabetes mellitus groups with chronic periodontitis (P resting (9.64 mmol/L) > control (8.82 mmol/L) (P < 0.05). Conclusion The severi⁃ ty of chronic periodontitis plays no role in the level of HbA1c, instead, the level of fasting plasma glucose changes with the severity and progression of chronic periodontitis.

Keywords

• Type 2 diabetes mellitus
• Chronic periodontitis
• Degree of lesions
• Active period