Nature Communications (Sep 2022)
Identification of risk loci for primary aldosteronism in genome-wide association studies
- Edith Le Floch,
- Teresa Cosentino,
- Casper K. Larsen,
- Felix Beuschlein,
- Martin Reincke,
- Laurence Amar,
- Gian-Paolo Rossi,
- Kelly De Sousa,
- Stéphanie Baron,
- Sophie Chantalat,
- Benjamin Saintpierre,
- Livia Lenzini,
- Arthur Frouin,
- Isabelle Giscos-Douriez,
- Matthis Ferey,
- Alaa B. Abdellatif,
- Tchao Meatchi,
- Jean-Philippe Empana,
- Xavier Jouven,
- Christian Gieger,
- Melanie Waldenberger,
- Annette Peters,
- Daniele Cusi,
- Erika Salvi,
- Pierre Meneton,
- Mathilde Touvier,
- Mélanie Deschasaux,
- Nathalie Druesne-Pecollo,
- Sheerazed Boulkroun,
- Fabio L. Fernandes-Rosa,
- Jean-François Deleuze,
- Xavier Jeunemaitre,
- Maria-Christina Zennaro
Affiliations
- Edith Le Floch
- Centre National de Recherche en Génomique Humaine, Institut de biologie François Jacob, CEA, Université Paris-Saclay
- Teresa Cosentino
- Université Paris Cité, Inserm, PARCC
- Casper K. Larsen
- Université Paris Cité, Inserm, PARCC
- Felix Beuschlein
- Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-University
- Martin Reincke
- Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-University
- Laurence Amar
- Université Paris Cité, Inserm, PARCC
- Gian-Paolo Rossi
- DMCS ‘G. Patrassi’ University of Padova Medical School, University Hospital
- Kelly De Sousa
- Université Paris Cité, Inserm, PARCC
- Stéphanie Baron
- Université Paris Cité
- Sophie Chantalat
- Centre National de Recherche en Génomique Humaine, Institut de biologie François Jacob, CEA, Université Paris-Saclay
- Benjamin Saintpierre
- Université Paris Cité, Institut Cochin, Genom’IC platform, INSERM, CNRS
- Livia Lenzini
- DMCS ‘G. Patrassi’ University of Padova Medical School, University Hospital
- Arthur Frouin
- Centre National de Recherche en Génomique Humaine, Institut de biologie François Jacob, CEA, Université Paris-Saclay
- Isabelle Giscos-Douriez
- Université Paris Cité, Inserm, PARCC
- Matthis Ferey
- Université Paris Cité, Inserm, PARCC
- Alaa B. Abdellatif
- Université Paris Cité, Inserm, PARCC
- Tchao Meatchi
- Université Paris Cité, Inserm, PARCC
- Jean-Philippe Empana
- Université Paris Cité, Inserm, PARCC
- Xavier Jouven
- Université Paris Cité, Inserm, PARCC
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Daniele Cusi
- Institute of Biomedical Technologies National Research Council of Italy
- Erika Salvi
- Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’
- Pierre Meneton
- UMR_1142, INSERM, Sorbonne Université, Université Paris 13
- Mathilde Touvier
- Sorbonne Paris Nord University, INSERM U1153, INRAe U1125, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center – Université Paris Cité (CRESS)
- Mélanie Deschasaux
- Sorbonne Paris Nord University, INSERM U1153, INRAe U1125, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center – Université Paris Cité (CRESS)
- Nathalie Druesne-Pecollo
- Sorbonne Paris Nord University, INSERM U1153, INRAe U1125, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center – Université Paris Cité (CRESS)
- Sheerazed Boulkroun
- Université Paris Cité, Inserm, PARCC
- Fabio L. Fernandes-Rosa
- Université Paris Cité, Inserm, PARCC
- Jean-François Deleuze
- Centre National de Recherche en Génomique Humaine, Institut de biologie François Jacob, CEA, Université Paris-Saclay
- Xavier Jeunemaitre
- Université Paris Cité, Inserm, PARCC
- Maria-Christina Zennaro
- Université Paris Cité, Inserm, PARCC
- DOI
- https://doi.org/10.1038/s41467-022-32896-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Detection of primary aldosteronism, the most common form of secondary arterial hypertension, is essential for targeted management and prevention of cardiovascular complications. Here, the authors identify genetic loci associated with primary aldosteronism, suggesting new mechanisms of disease.
