Nature Communications (Jul 2018)
ATR is a multifunctional regulator of male mouse meiosis
- Alexander Widger,
- Shantha K. Mahadevaiah,
- Julian Lange,
- Elias ElInati,
- Jasmin Zohren,
- Takayuki Hirota,
- Sarai Pacheco,
- Andros Maldonado-Linares,
- Marcello Stanzione,
- Obah Ojarikre,
- Valdone Maciulyte,
- Dirk G. de Rooij,
- Attila Tóth,
- Ignasi Roig,
- Scott Keeney,
- James M.A. Turner
Affiliations
- Alexander Widger
- Sex Chromosome Biology Lab, The Francis Crick Institute
- Shantha K. Mahadevaiah
- Sex Chromosome Biology Lab, The Francis Crick Institute
- Julian Lange
- Molecular Biology Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center
- Elias ElInati
- Sex Chromosome Biology Lab, The Francis Crick Institute
- Jasmin Zohren
- Sex Chromosome Biology Lab, The Francis Crick Institute
- Takayuki Hirota
- Sex Chromosome Biology Lab, The Francis Crick Institute
- Sarai Pacheco
- Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona
- Andros Maldonado-Linares
- Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona
- Marcello Stanzione
- Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden
- Obah Ojarikre
- Sex Chromosome Biology Lab, The Francis Crick Institute
- Valdone Maciulyte
- Sex Chromosome Biology Lab, The Francis Crick Institute
- Dirk G. de Rooij
- Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam
- Attila Tóth
- Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden
- Ignasi Roig
- Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona
- Scott Keeney
- Molecular Biology Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center
- James M.A. Turner
- Sex Chromosome Biology Lab, The Francis Crick Institute
- DOI
- https://doi.org/10.1038/s41467-018-04850-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.
